Uncovering the selectivity mechanism of PDE4B and PDE4D

pede4dThe PDE4 family contains four genes (PDE4A to PDE4D), only PDE4A, PDE4B, and PDE4D are expressed in the heart, each of which regulates different cAMP-dependentThe goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral outcomes in patients